Predicting Drug Safety: Next Generation Solutions

Safety-Critical Systems: The Next Generation

The next generation of antibody drug conjugates.

Antibody-drug conjugates (ADCs) represent a promising therapeutic modality for the clinical management of cancer. The recent approvals of brentuximab vedotin and ado-trastuzumab emtansine plus emerging data for many molecules in clinical trials highlight the potential for ADCs to offer new therapeutic options for patients. Currently, more than 30 ADCs are being evaluated in early- or late-stage...

Drug-eluting stents: the next generation

The small but absolute increase in late and very late stent thrombosis associated with drug-eluting stent technology may in part be related to the permanent, durable polymers currently employed with these stent platforms. Research has recently focused on two strategies to combat this problem; bioabsorbable polymers and polymer-free stents. This article critically reviews the key clinical trials...

Next generation sequencing in predicting gene function in podophyllotoxin biosynthesis.

Podophyllum species are sources of (-)-podophyllotoxin, an aryltetralin lignan used for semi-synthesis of various powerful and extensively employed cancer-treating drugs. Its biosynthetic pathway, however, remains largely unknown, with the last unequivocally demonstrated intermediate being (-)-matairesinol. Herein, massively parallel sequencing of Podophyllum hexandrum and Podophyllum peltatum ...

e-Bioscience Solutions and Challenges for Next Generation Sequencing Experiments

Next generation sequencing (NGS) produces large volumes of data. To keep the processing time within bounds, there is the need to optimize the bioinformatics analysis pipelines. We have been using scientific workflow technology for agile development of analysis pipelines and grid infrastructure to accelerate the processing. Although these methods were successfully applied to a diverse range of s...